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Analyte: Apolipoprotein C-II
Specimen Type: Serum and EDTA plasma
Optimum Volume: 0.5 mL
|1 week||3 months||2.5 year|
Reporting units: mg/dL
Biological or Clinical Significance:
Apolipoproteins are components of lipoproteins in plasma and are important in determining the structure, function and metabolism of lipoproteins. Apolipoprotein C-II is contained in very low density lipoproteins (VLDL) and high density lipoproteins (HDL), and activates lipoprotein lipase (LPL) on the surface of endothelial cells. In type II dyslipidemia patients a strong positive correlation between plasma TG and apo C-II and C-III concentrations exists. However, the most pronounced increase in plasma apolipoproteins is observed in type V dyslipidemia patients. In these patients, plasma TG are positively correlated with apo C-III and inversely correlated with apo C-II.
Principle of Test Method:
The apo C-II assay is an automated immunoturbidimetric method.
1. Graziani MS, Zanolla L, Righetti G, Marchetti C, Zanotto G, Lupo A. Distribution of CII and CIII peptides in lipoprotein classes: methods and clinical significance. Clin Chem. 1994; 40:240-244.
2. Tian L, Xu Y, Fu M, Jia L, Yang Y. Influence of apolipoprotein CII concentrations on HDL subclass distribution. J Atheroscler Thromb. 2009; 16: 611-620.