Biomarker Menu

document-download

Download this assay page in pdf format.

Download

IL-17 (Interleukin-17)

Analyte: Interleukin-17

Specimen Type: Serum, Inquire for additional option(s)

Optimum Volume: 0.5 mL

Stability:

2-8°C -20°C -70°C
1 day N.A. 1 year

Reporting units: pg/mL

Method: ECLIA (Electrochemiluminescent Immunoassay)

Biological or Clinical Significance:

Interleukin-17 (IL-17), originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), is produced by activated T lymphocytes, primarily by memory T cells. IL-17 is the founding member of a cytokine family (also called IL-17A), and appears to mediate communication between the immune system and the hematopoietic system. IL-17 is a disulfide-linked homodimer.

IL-17 mediation of T cell communication with the hematopoietic system is suggested by two observations. T cell-derived IL-17 induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF, apparently by an NF-κB-mediated mechanism. IL-6 in turn promotes development of granulocyte/macrophage colonies, and G-CSF directs development of neutrophils. IL-17 also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) production in osteoarthritic cartilage.

Principle of Test Method:

The IL-17 assay is a sandwich immunoassay using electrochemiluminescent detection.

References:

2. Yasumi Y, Takikawa Y, Endo R, Suzuki K. Interleukin-17 as a new marker of severity of acute hepatic injury. Hepatol Res. 2007; 37:248-254.
3. Arican O, Aral M, Susmaz S, Ciragil P. Serum levels of TNF-a, IFN-?, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators of Inflammation 2005:5:273-279.
4. Gaffen SL. Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bones biology and arthritis. Arthritis Res Ther. 2004: 6:240-247.

Related Assays

Downloadable, Printable Biomarker Menus

Alphabetical Listing

Download PDF

Biomarker Category

Download PDF