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Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
Neopterin (2-amino-4-oxo-6-(D-erythro-1, 2, 3, trihydroxypropyl)-pteridine) is a product of activated macrophages and an indicator of the inflammatory process. It can be measured in serum, plasma, and urine. The increase of neopterin levels may be used for monitoring diseases associated with the activation of cell-mediated immunity. Increases in neopterin concentration have been used to predict immunologic complications in transplant recipients, HIV infection prognosis and most recently investigated for a potential role in prediction of adverse cardiac events. Neopterin levels increase prior to the clinical manifestation of some of these conditions.