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Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. The calgranulins are S100 proteins that are expressed in neutrophils, and are abundant in infiltrating monocytes and granulocytes under conditions of chronic inflammation.
RAGE is a central cell surface receptor for S100A12. . Interaction of EN-RAGE (S100A12) with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key pro-inflammatory mediators. S100A12 serum concentrations indicate neutrophil activation in juvenile rheumatoid arthritis, cystic fibrosis, Kawasaki disease, and Crohn's disease. Its function as a pro-inflammatory factor secreted by activated neutrophils makes this protein a potential target for future therapies.