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Analyte: Cholesteryl Ester Transfer Protein - Mass
Specimen Type: Serum, EDTA Plasma, Citrate Plasma
Optimum Volume: 0.5 mL
|12 days||2 months||3.5 years|
Reporting units: ug/mL
Biological or Clinical Significance:
Plasma cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl ester (CE) from high density lipoprotein (HDL) to apolipoprotein B-containing lipoproteins. Since CETP regulates the plasma levels of HDL cholesterol and the size of HDL particles, CETP is considered to be a key protein in reverse cholesterol transport, a protective system against atherosclerosis. The importance of plasma CETP in lipoprotein metabolism was demonstrated by the discovery of CETP-deficient subjects with marked hyperalphalipoproteinemia.
Principle of Test Method:
The CETP assay is a solid-phase ELISA designed to measure human CETP mass in serum and plasma. It employs the quantitative sandwich enzyme immunoassay principle.
1.Yoshida A, Kodama M, Nomura H, Kobayashi N, Sumida K, Naito M. Variability in cholesteryl ester transfer protein in healthy Japanese hyper-HDL-cholesterolemic subjects. Intern Med. 2002 41:357-359.
2.Sasai K, Okumura-Noji K, Hibino T, Ikeuchi R, Sakuma N, Fujinami T, Yokoyama S. Human cholesteryl ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholesteryl ester transfer protein: plasma cholesteryl ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients. Clin Chem. 1998;44:1466-1473.
3.Barter PJ, Brewer, Jr. B, Chapman MJ, Hennekens CH, Rader DJ and Tall AR. Chosteryl Ester Transfer Protein: A novel target for raising HDL and inhibiting atherosclerosis. Aterioscler Thromb Vasc Biol. 2003; 23:160-167.