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CXCL-10 (IP-10)

Analyte: CXCL-10 (IP-10)

Specimen Type: Serum

Optimum Volume: 0.5 mL

Stability:

2-8°C -20°C -70°C
5 days TBD TBD

Reporting units: pg/mL

Method: ELISA

Biological or Clinical Significance:

IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, was originally indentified as an IFN-γ-inducible gene.  It is induced in a variety of cells in response to IFN-γ and LPS.  In contrast to other CXC chemokines, IP-10 has no chemotactic activity for neutrophils.  It is a pleiotropic molecule that appears to target activated T cells and monocytes.  IP-10 inhibits bone marrow colony formation and angiogenensis.  It can also stimulate NK and T cell migration, regulate T cell maturation and modulate adhesion molecule expression.

IP-10 expression has been associated with HIV infection.  It can contribute to the accumulation of activated T cells in the cerebrospinal fluid compartment in HIV-1 infected individuals.  The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes.

IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients.  Astrocytes expressing IP-10 are commonly associated with senile plaques.

Principle of Test Method:

The IP-10 immunoassay is a solid-phase ELISA designed to measure human IP-10 in cell culture supernates, serum, plasma and saliva.  This assay employs the quantitative sandwich enzyme immunoassay technique. 

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