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Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
Recent observations have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis, which is an independent prognostic indicator of recurrence and disease-free survival. The hepatocyte growth factor (HGF)/mesenchymal–epithelial transition factor (c-Met) pathway plays a key role in the carcinogenic pathway. Hepatocyte growth factor (HGF) is a glycoprotein secreted by a variety of mesenchymal or tumor cells, which promote migration, invasion, wound healing and survival and suppress apoptosis by c-Met. Met transmits intracellular signals via the mitogen-activated protein kinase (MAPK) and PI3K–AKT pathways. MACC1 was reported to be elevated in various cancer tissues, including ovarian cancer, hepatocellular carcinoma, non-small cell lung cancer, and oral squamous cell carcinoma. Recently, there have been reports demonstrating that MACC1 may be involved in the growth of blood vessels, lymphangiogenesis and metastasis of gastric cancer, but little is known regarding its role in gastric cancer development.
The hepatocyte growth factor (HGF) is a multifunctional cytokine and its biologic activity is mediated by C-Met. The growth, invasion and metabasis of many human tumer cells are closely in relation to HGF/C-Met.