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Analyte: Vasclular Endothelial Growth Factor-C
Specimen Type: Serum
Optimum Volume: 0.4 mL
|3 days||3 months||3 months|
Reporting units: pg/mL
Biological or Clinical Significance:
Vascular endothelial growth factor C is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers. It binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.
Principle of Test Method:
The VEGF-C assay is a chemiluminescent immunoassay. Detection range 15.6 - 16000 MRD 1:2