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Analyte: Placental Growth Factor
Specimen Type: Serum
Optimum Volume: 0.4 mL
|Unstable||3 months||3 months|
Reporting units: pg/mL
Biological or Clinical Significance:
PlGF (Placental Growth Factor) is a member of the VEGF family of growth factor that share a conserved pattern of eight cysteines.PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF binds both but signals only through the angiogenic receptor, VEGF R2. PlGF and VEGF therefore compete for binding to VEGF R1. High PlGF inhibits VEGF/VEGF R1 binding and promotes VEGF/VEGF R2 mediated angiogenesis . It plays important roles in angiogenesis, vasculogenesis and lymphangiogenesis.
Principle of Test Method:
The PIGF assay is a chemiluminescent immunoassay.