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VEGF-R2 (Vasclular Endothelial Growth Factor-R2)

Analyte: Vasclular Endothelial Growth Factor-R2

Specimen Type: Serum

Optimum Volume: 0.4 mL

Stability:

2-8°C -20°C -70°C
3 days 3 months 3 months

Reporting units: pg/mL

Method: Chemiluminescence

Biological or Clinical Significance:

VEGF-R2 ( Vascular Endothelial Growth Factor Receptor 2) belongs to the class III subfamily of receptor tyrosine kinases (RTKs). PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF binds both but signals only through the angiogenic receptor, VEGF R2. PlGF and VEGF therefore compete for binding to VEGF R1. High PlGF inhibits VEGF/VEGF R1 binding and promotes VEGF/VEGF R2 mediated angiogenesis . It plays important roles in angiogenesis, vasculogenesis and lymphangiogenesis.

Principle of Test Method:

The VEGF-R2 assay is a chemiluminescent immunoassay. Detection range 6.8 - 7000  MRD 1:5

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