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Anti-CCP (Anti-Cyclic Citrullinated Peptide)

Analyte: Anti-Cyclic Citrullinated Peptide

Specimen Type: Serum, Inquire for additional option(s)

Optimum Volume: 0.5 mL


2-8°C -20°C -70°C
1 week 2 year 2 years

Reporting units: U/mL

Method: ELISA

Biological or Clinical Significance:

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by the inflammation of the membrane lining joints. The most frequent serological test in the diagnosis of RA is the measurement of rheumatoid factor (RF). RF is not specific for RA as it is often present in healthy individuals and patients with other autoimmune diseases and chronic infections. It has been known for years that anti-perinuclear autoantibodies, also called anti-keratin, are found in people with RA. Recently it was discovered that these autoantibodies recognize an epitope that contains the deimidated form of arginine called citrulline.

Principle of Test Method:

The anti-CCP assay is an enzyme linked immunoassay.


1. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, Kamae I, Kumagai S. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007 Jun 5; 146(11):797-808.
2. Mori S, Hirose J, Yonemura K. Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-citrullinated antibodies to development of resistance to disease-modifiying antirheumatic drugs in early rheumatoid arthritis. Clin Rheumatol. 2010 Apr 11. [Epub ahead of print]

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