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PIIINP (N-Terminal Propeptide of Type III Collagen)

Analyte: Procollagen Type III N-Propeptide

Specimen Type: Serum, Heparin Plasma, Inquire for additional options(s)

Optimum Volume: 1.0 mL

Stability:

2-8°C -20°C -70°C
5 days 2 years 2 years

Reporting units: ng/mL

Method: RIA

Biological or Clinical Significance:

Type III (PIIINP) collagen is derived from a larger protein, type III procollagen. Increased concentrations of PIIINP are found in a number of conditions where accumulation and/or degradation of connective tissue takes place, e.g. in fibroproliferative, haematological, endocrinological and malignant diseases. Thus changes in PIIINP levels are not specific for a particular disease but reflect the involvement and altered metabolism of type III collagen. In growth deficient children, the induction of growth is reflected in increasing serum PIIINP. Liver fibrosis and cirrhosis of various aetiologies increase serum concentration of PIIINP. Serum PIIINP is increased in myeloproliferative diseases, particularly during the active phases of myelofibrosis. The serum concentration of PIIINP also appears to reflect the repair process and scar formation after a myocardial infarction.

Principle of Test Method:

The PIIINP RIA kit is based on the competitive radioimmunoassay technique.

References:

1. Sundström J, Vasan RS Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events. Curr Opin Lipidol.
2. Meyer O. Prognostic markers for systemic sclerosis. Joint Bone Spine. 2006 Oct;73(5):490-4. Epub 2006 Jun 2.
3. Bolarin DM, Azinge EC. Biochemical markers, extracelluar components in liver fibrosis and cirrhosis. Nig Q J Hosp Med. 2007
4. Ehlers, Mario R., and Elizabeth T. Leary. "Biochemical Markers of Rheumatoid Arthritis and Osteoarthritis: Clinical Utility and Practical Considerations." Clinical Trials in Rheumatoid Arthritis and Osteoarthritis. London: Springer, 2008. 151-69. Print.

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