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Analyte: Complement Factor C3c
Specimen Type: Serum, Inquire for additional option(s)
Optimum Volume: 0.5 mL
|8 days||1 month||3.5 years|
Reporting units: mg/dL
Biological or Clinical Significance:
Activation of the complement system takes place via a classical and an alternative route. The two pathways come together in a joint terminal path. As complement factor C3 is common to both pathways, the concentration of C3 and its degradation products (including C3c) can be evaluated as a parameter for activation of the complement system. Lowered values are indicative of activation. Additional differentiation can be made by determining C4.
A considerable decrease in C3 can be found in patients with partial lipodystrophy or membranoproliferative glomerulonephritis when the C3-nephritis factor is present. As an acute phase protein, C3 is produced to an increased extent during inflammatory processes. It is elevated in systemic infections, non- infectious chronic inflammatory conditions (primarily chronic polyarthritis) and physiological states (pregnancy).
Principle of Test Method:
The Compliment Factor C3c assay is an automated immunoturbidimetric method.
1. Tsukamoto H, Horiuchi T. Clinical aspects of the complement system. Rinsho Byori. 2006 Jul;54(7):757-62.