Biomarker Menu

Biomarker Category: Inflammation and Immunity

Adipsin (Complement Factor D)

Analyte: Complement Factor D
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

The complement system comprises approximately 30 circulating plasma proteins, as well as cell-surface receptors, that function as part of the innate and adaptive immune system to eliminate pathogens.  The...
https://pacbio.com/biomarker/assay-detail/307

Ang-2 (Angiopoietin-2)

Analyte: Angiopoietin-2
Specimen Type: Serum
Biological or Clinical Significance:

 Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.  It belongs to the angiopoietin protein family (angiopoietin-1, -2, -3, and -4) which plays an important role in the development...
https://pacbio.com/biomarker/assay-detail/382

BAFF (B-cell Activating Factor)

Analyte: B-cell Activating Factor
Specimen Type: Serum, EDTA plasma, Inquire for additional option(s)
Biological or Clinical Significance:

B-cell activating factor (BAFF), is a TNF superfamily member (TNSF13B) best known for its role in the survival and maturation of B cells. BAFF is produced by several cell types and tissues including monocytes,...
https://pacbio.com/biomarker/assay-detail/81

BMP-9 (Bone Morphogenic Protein-9)

Analyte: Bone Morphogenic Protein-9
Specimen Type: Serum
Biological or Clinical Significance:

Bone Morphogenetic Protein 9 (BMP-9), also known as growth differentiation factor 2 (GDF2), is encoded by the human CDF2  gene.  It belongs to the TGF-β cytokine family whose members play an important...
https://pacbio.com/biomarker/assay-detail/390

C-MET

Analyte: C-MET
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Recent observations have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis, which is an independent prognostic indicator of recurrence...
https://pacbio.com/biomarker/assay-detail/383

CK-18/M30 Fragment Asp 396

Analyte: Cytokeratin 18 Fragments (Asp 396)
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

Caspases cleave various cellular proteins during apoptosis.  In epithelial cells, one of those substrates is the intermediate filament protein keratin 18 (K18).  The M30 antibody recognizes a neo-epitope...
https://pacbio.com/biomarker/assay-detail/300

CK-18/M65 ED (Cytokeratin 18)

Analyte: Cytokeratin 18
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

Cytokeratin 18 (CK18) is an intracellular protein expressed at high levels in most cell types of epithelial origin, including the most common forms of human carcinomas.  It is not expressed by cells of the...
https://pacbio.com/biomarker/assay-detail/401

Complement Factor C3c

Analyte: Complement Factor C3c
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Activation of the complement system takes place via a classical and an alternative route. The two pathways come together in a joint terminal path. As complement factor C3 is common to both pathways, the concentration...
https://pacbio.com/biomarker/assay-detail/90

Complement Factor C4

Analyte: Complement Factor C4
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

The complement system can be activated via the classical and the alternative route. Complement factor C4 participates in activation by the classical route. A decrease in C4 is common, but complete absence is...
https://pacbio.com/biomarker/assay-detail/91

Complement Factor D (Adipsin)

Analyte: Complement Factor D
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

The complement system comprises approximately 30 circulating plasma proteins, as well as cell-surface receptors, that function as part of the innate and adaptive immune system to eliminate pathogens.  The...
https://pacbio.com/biomarker/assay-detail/367

Complement Membrane Attack Complex (SC5b-9)

Analyte: SC5b-9
Specimen Type: Please contact PBI for collection instructions
Biological or Clinical Significance:

The terminal complement complex (TCC, SC5b-9) is generated by the assembly of C5b through C9 as a consequence of activation of the complement system by either the classical, lectin, or alternative pathways. ...
https://pacbio.com/biomarker/assay-detail/213

CXCL-10 (IP-10)

Analyte: CXCL-10 (IP-10)
Specimen Type: Serum
Biological or Clinical Significance:

IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, was originally indentified as an IFN-γ-inducible gene.  It is induced in a variety of cells in response to IFN-γ and LPS. ...
https://pacbio.com/biomarker/assay-detail/312

CXCL-12 SDF-1 (Stromal Cell Derived Factor-1)

Analyte: Stromal Cell Derived Factor-1
Specimen Type: PlatletPoor EDTA Plasma
Biological or Clinical Significance:

SDF-1 alpha or stromal derived factor 1 alpha (also known as  CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines...
https://pacbio.com/biomarker/assay-detail/339

E-Selectin

Analyte: E-Selectin
Specimen Type: Heparin Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E) is a 115 kDa, type-1 transmembrane glycoprotein expressed only on endothelial cells and only after activation by inflammatory cytokines (IL-1...
https://pacbio.com/biomarker/assay-detail/103

Endoglin

Analyte: Endoglin
Specimen Type: Serum
Biological or Clinical Significance:

Endoglin, also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for transforming growth factor beta (TGF-β) superfamily ligands. It is highly expressed on vascular...
https://pacbio.com/biomarker/assay-detail/389

FAS (APO1) (CD95)

Analyte: FAS
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Fas (APO-1 or CD95) is a cell-surface receptor that transduces apoptotic signals from Fas ligand (FasL).  It is a glycoprotein with a mass estimated at 43 to 48 kDa.  Fas is a member of the Tumor Necrosis...
https://pacbio.com/biomarker/assay-detail/225

FDP (Fibrinogen Degredation Products)

Analyte: Fibrinogen Degredation Products
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/430

Fibrinogen

Analyte: Fibrinogen
Specimen Type: EDTA Plasma (Preferred), Citrate Plasma (Acceptable)
Biological or Clinical Significance:

Fibrinogen is a soluble precursor of the insoluble fibrin, the major component of blood clots. It is a 340,000 Dalton glycoprotein composed of six subunits. When fibrinogen is activated by the proteolytic enzyme...
https://pacbio.com/biomarker/assay-detail/106

gp130 (Gycoprotein 130)

Analyte: Gycoprotein 130
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

Interleukin 6 (IL-6) is a multifunctional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis.  IL-6 exerts its activity through binding to a high...
https://pacbio.com/biomarker/assay-detail/164

Haptoglobin

Analyte: Haptoglobin
Specimen Type: Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma
Biological or Clinical Significance:

Haptoglobin is a transport and acute-phase protein that is synthesized in hepatocytes. It is a glycoprotein which consists of two light α-chains and two heavy β-chains. The genetic polymorphism of the α-chains...
https://pacbio.com/biomarker/assay-detail/34

HGF (Human Growth Factor)

Analyte: Human Growth Hormone
Specimen Type: Serum
Biological or Clinical Significance:

Hepatocyte growth factor (HGF), also known as Hepatopoietin A, is mitogenic for a variety of cell types, including endothelial and epithelial cells, melanocytes, and keratinocytes. HGF signals through a transmembrane...
https://pacbio.com/biomarker/assay-detail/392

HMGB1 (High Motility Group Box 1 Protein)

Analyte: High Mobility Group Box 1
Specimen Type: Serum
Biological or Clinical Significance:

HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone nuclear protein group.  HMGB1 is a transcriptional regulator and is normally present...
https://pacbio.com/biomarker/assay-detail/313

hs-CRP (Highly-Sensitive C-Reactive Protein)

Analyte: C-Reactive Protein
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

C-reactive protein is the classic acute phase protein in inflammatory reactions. It is synthesized by the liver and consists of five identical polypeptide chains forming a five-membered ring of molar mass 120,000...
https://pacbio.com/biomarker/assay-detail/39

ICAM-1 (Intra-Cellular Adhesion Molecule-1)

Analyte: Intra-Cellular Adhesion Molecule-1
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Adhesion molecules mediate the interaction of cells with the extracellular matrix and with other cells. The immunoglobulin proteins contain a large class of adhesion molecules with, multiple immunoglobulin-like...
https://pacbio.com/biomarker/assay-detail/166

ICAM-1 (Intra-Cellular Adhesion Molecule-1) - Chemiluminescence

Analyte: Intra-Cellular Adhesion Molecule-1
Specimen Type: Serum
Biological or Clinical Significance:

ICAM-1 (Intercellular Adhension Molecule 1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after...
https://pacbio.com/biomarker/assay-detail/409

IFN-γ (Interferon gamma)

Analyte: Interferon-γ
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Interferon-gamma, IFN-gamma, also known as immune interferon, is one of a group of functionally related polypeptide hormones that exhibit potent anti-viral activity, both in vitro and in vivo....
https://pacbio.com/biomarker/assay-detail/121

IL-1 Ra (Interleukin 1 Receptor Antagonist)

Analyte: Interleukin-1 receptor antagonist
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin-1 receptor antagonist (IL-1ra; also know as IL-1F3) is a 22 – 25 kDa member of the IL-1 family of cytokines. It is an acute phase protein that exists to dampen inflammation. IL-1 (β) is initially...
https://pacbio.com/biomarker/assay-detail/200

IL-10 (Interleukin-10)

Analyte: Interleukin-10
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

Interleukin-10 (IL-10) is a potent modulator of monocyte/macrophage function. Human IL-10 cDNAs encode 178 amino acid (aa) residue precursor polypeptides with hydrophobic signal peptides that are cleaved to generate...
https://pacbio.com/biomarker/assay-detail/41

IL-17 (Interleukin-17)

Analyte: Interleukin-17
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin-17 (IL-17), originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), is produced by activated T lymphocytes, primarily by memory T cells. IL-17 is the founding member of...
https://pacbio.com/biomarker/assay-detail/126

IL-17A (Interleukin-17A), ultrasensitive

Analyte: Interleukin-17A
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

Interleukin17A (IL-17A) is the founding member of a group of cytokines called the IL-17 family.  There are several members of the IL-17 family, from IL-17A to IL-17F (IL-17E is also called IL-25). ...
https://pacbio.com/biomarker/assay-detail/397

IL-17A/F (Interleukin-17A/F), ultrasensitive

Analyte: Interleukin-17A/F
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers...
https://pacbio.com/biomarker/assay-detail/399

IL-17F (Interleukin-17F), ultrasensitive

Analyte: Interleukin-17F
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory...
https://pacbio.com/biomarker/assay-detail/398

IL-18 (Interleukin 18), Urine

Analyte: Interleukin-18
Specimen Type: Urine
Biological or Clinical Significance:

Interleukin 18 (IL-18) is a 18kDa novel cytokine which is identified as a costimulatory factor for production of interferon-γ (IFN- γ) in response to toxic shock. It shares functional similarities with IL-12....
https://pacbio.com/biomarker/assay-detail/422

IL-18 (Interleukin-18)

Analyte: Interleukin-18
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin 18 (IL-18) is an 18kDa novel cytokine, which has been identified as a co-stimulatory factor for production of interferon-gamma (IFN- γ) in response to toxic shock. It shares functional similarities...
https://pacbio.com/biomarker/assay-detail/127

IL-1ß (Interleukin-1ß)

Analyte: Interleukin-1β
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Interleukin 1 (IL-1) includes two distinct proteins, IL-1α and IL-1β, that play central roles in acute and chronic inflammation, both locally and systemically. Human IL-1β is synthesized as a procytokine (269...
https://pacbio.com/biomarker/assay-detail/125

IL-2 Ra (Interleukin 2 Soluble Receptor alpha)

Analyte: sIL-2Rα
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

The biological activities of IL-2 are mediated by its binding to a multi-molecular cellular receptor complex. The receptor consists of three glycoprotein chains, an alpha chain (IL-2 Rα), a beta chain (IL-2...
https://pacbio.com/biomarker/assay-detail/66

IL-6 (Interleukin-6)

Analyte: Interleukin - 6
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin 6 (IL-6) is a multifunctional cytokine that has a major role in initiation and promulgation of the inflammatory and immune responses.

The biological activities of IL-6 are initiated by...
https://pacbio.com/biomarker/assay-detail/42

IL-6 sR (Interleukin 6 Soluble Receptor)

Analyte: Interleukin 6 soluble receptor
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin 6 (IL-6) is a multifunctional cytokine that has a major role in initiation and promulgation of the inflammatory and immune responses.  It is produced by a wide variety or cell types including...
https://pacbio.com/biomarker/assay-detail/427

IL-8 (Interleukin-8)

Analyte: Interleukin-8
Specimen Type: Serum
Biological or Clinical Significance:

Interleukin 8 (IL-8) or CXCL8 is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells. It induces chemotaxis in target cells, primarily neutrophils but...
https://pacbio.com/biomarker/assay-detail/393

IP-10 (Interferon Gamma-Induced Protein 10)

Analyte:  Interferon Gamma-Induced Protein 10
Specimen Type: Serum
Biological or Clinical Significance:

IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, was originally indentified as an IFN-γ-inducible gene.  It is induced in a variety of cells in response to IFN-γ and LPS. ...
https://pacbio.com/biomarker/assay-detail/226

M-CSF-1 (Macrophage Colony Stimulating Factor)

Analyte: Macrophage Colony Stimulating Factor
Specimen Type: Serum, Lithium Heparin Plasma
Biological or Clinical Significance:

M-CSF, also known as CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that could stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor...
https://pacbio.com/biomarker/assay-detail/426

MCP-1 (Monocyte Chemotactic Protein-1) - chemi

Analyte: Monocyte Chemotactic Protein-1
Specimen Type: Serum
Biological or Clinical Significance:

Monocyte Chemotactic Protein-1 (MCP-1), also known as CCL2, MCAF and TDCF, is encoded by the human JE gene. It belongs to the CC chemokine family. The MCP proteins chemoattract and activate monocytes, activated...
https://pacbio.com/biomarker/assay-detail/407

MCP-1 (Monocyte Chemotactic Protein-1) -ELISA

Analyte: Monocyte Chemotactic Protein-1
Specimen Type: Serum, EDTA plasma
Biological or Clinical Significance:

Monocyte chemotactic protein 1 (MCP-1/CCL2), also known as monocyte chemotactic and activating factor (MCAF), is a member of the CC subgroup of the chemokine superfamily.  MCP-1 has the ability to act as...
https://pacbio.com/biomarker/assay-detail/139

MIP-1α (Macrophage Inflammatory Protein-1 alpha)

Analyte: Macrophage Inflammatory Protein-1 alpha
Specimen Type: Serum
Biological or Clinical Significance:

Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha) is a member of the β or CC subfamily of chemokines and is also referred to as Chemokine (C-C motif) Ligand 3 or CCL3. Additional chemokine subfamilies,...
https://pacbio.com/biomarker/assay-detail/194

MIP-3β (Macrophage Inflammatory Protein-3 beta)

Analyte: Macrophage Inflammatory Protein-3 beta
Specimen Type: Serum
Biological or Clinical Significance:

MIP-3 beta also referred to as CCL19, ELC, Exodus-3, and SCYA19 is a CC chemokine that is expressed in secondary lymphoid organs like the thymus, lymph nodes as well as in activated bone marrow stromal cells....
https://pacbio.com/biomarker/assay-detail/334

MMP-1 (Matrix Metalloproteinase)

Analyte: Matrix Metalloproteinase-1
Specimen Type: Heparin Plasma
Biological or Clinical Significance:

Matrix metalloproteinases (MMPs) constitute a family of zinc and calcium dependent endopeptidases that function in the breakdown of extracellular matrix (ECM). They play an important role in many normal physiological...
https://pacbio.com/biomarker/assay-detail/141

MMP-2 (Matrix Metalloproteinase)

Analyte: Matrix Metalloproteinase-2
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/197

MMP-3 (Matrix Metalloproteinase)

Analyte: Matrix Metalloproteinase-3
Specimen Type: Serum, Heparin Plasma
Biological or Clinical Significance:

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix proteins. They are secreted as zymogens (pro-MMPs) that are activated by a variety of proteinases....
https://pacbio.com/biomarker/assay-detail/142

MMP-7 (Matrix Metalloproteinase)

Analyte: Matrix Metalloproteinase-7
Specimen Type: Serum, Lithium Heparin Plasma
Biological or Clinical Significance:

Matrix metalloproteinases (MMPs), also called matrixins, constitute a family of zinc and calcium dependent endopeptidases that function in the breakdown of extracellular matrix (ECM).  They play an important...
https://pacbio.com/biomarker/assay-detail/227

MMP-9 (Matrix Metalloproteinase)

Analyte: Matrix Metalloproteinase-9
Specimen Type: Platelet poor Heparin Plasma, inquire for additional option(s)
Biological or Clinical Significance:

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix proteins. They are secreted as zymogens (pro-MMPs) that are activated by a variety of proteinases....
https://pacbio.com/biomarker/assay-detail/143

Myeloperoxidase (MPO)

Analyte: Myeloperoxidase
Specimen Type: Heparin Plasma
Biological or Clinical Significance:

MPO is an enzyme that is synthesized and stored within polymorphonuclear leukocytes (PMN’s) and monocytes. MPO generates an array of reactive oxidants and free radical species as part of its role in host defenses....
https://pacbio.com/biomarker/assay-detail/144

Neopterin

Analyte: Neopterin
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Neopterin (2-amino-4-oxo-6-(D-erythro-1, 2, 3, trihydroxypropyl)-pteridine) is a product of activated macrophages and an indicator of the inflammatory process. It can be measured in serum, plasma, and urine....
https://pacbio.com/biomarker/assay-detail/146

P-Selectin

Analyte: P-Selectin
Specimen Type: EDTA Plasma, see note **
Biological or Clinical Significance:

P-selectin (GMP-140, LECAM-3, PADGEM, CD62, CD62P) is a cell surface glycoprotein that plays a critical role in the migration of lymphocytes into tissues.  It is found constitutively in a pre-formed state...
https://pacbio.com/biomarker/assay-detail/159

PAI -1 (Plasminogen Activator Inhibitor-1)

Analyte: Plasminogen Activator Inhibitor 1
Specimen Type: Frozen Citrate or EDTA Plasma
Biological or Clinical Significance:

Plasminogen activator inhibitor-1 (PAI – 1) is the principal inhibitor of tissue plasminogen activator and urokinase, the activators of plaminogen and hence fibrinolysis.

PAI-1 is present...
https://pacbio.com/biomarker/assay-detail/152

PARC (Pulmonary and Activation-Regulated Cytokine) (CCL-18)

Analyte: Pulmonary and Activation-regulated Cytokine
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Chemokines are small cytokines (8 – 10 kDa).  The major role of chemokines is to act as a chemoattractant to guide the migration of cells.  Some chemokines control cells of the immune system during...
https://pacbio.com/biomarker/assay-detail/296

PlGF (Placental Growth Factor)

Analyte: Placental Growth Factor
Specimen Type: Serum
Biological or Clinical Significance:

PlGF (Placental Growth Factor) is a member of the VEGF family of growth factor that share a conserved pattern of eight cysteines.PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF...
https://pacbio.com/biomarker/assay-detail/386

PMN Elastase

Analyte: Polymorphonuclear Elastase
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/433

Procalcitonin

Analyte: Procalcitonin
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/420

S100A12

Analyte: S100A12
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. The calgranulins are S100 proteins...
https://pacbio.com/biomarker/assay-detail/163

SAA (Serum Amyloid A)

Analyte: Serum Amyloid A
Specimen Type: Serum, EDTA Plasma, Inquire for addiitional option(s)
Biological or Clinical Significance:

Serum Amyloid A (SAA) is an acute-phase protein. During acute events, the rise in SAA levels is one of the most rapid and intense increases of all acute phase proteins. When elevated above normal levels SAA is...
https://pacbio.com/biomarker/assay-detail/63

SC5b-9 (Serum Complement Membrane Attack Complex)

Analyte: Serum Complement Membrane Attack Complex
Specimen Type: Please contact PBI for collection instructions
Biological or Clinical Significance:

The terminal complement complex (TCC, SC5b-9) is generated by the assembly of C5b through C9 as a consequence of activation of the complement system by either the classical, lectin, or alternative pathways. ...
https://pacbio.com/biomarker/assay-detail/278

SDF-1 (Stromal Cell Derived Factor-1) (CXCL-12)

Analyte: Stromal Cell Derived Factor-1
Specimen Type: Platelet Poor EDTA Plasma; please contact PBI for collection information
Biological or Clinical Significance:

SDF-1 alpha or stromal derived factor 1 alpha (also known as  CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines...
https://pacbio.com/biomarker/assay-detail/335

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance:

Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to...
https://pacbio.com/biomarker/assay-detail/408

TGF ß-1 (Transforming Growth Factor ß-1) - ELISA

Analyte: Transforming Growth Factor ß-1
Specimen Type: Platlet Poor EDTA Plasma; Please contact PBI for collection instructions
Biological or Clinical Significance:

Transforming growth factor (TGF), a ‘factor’ that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter...
https://pacbio.com/biomarker/assay-detail/171

TIMP-1 (Tissue Inhibitor of Metalloproteinase-1)

Analyte: Tissue Inhibitor of Metalloproteinases-1
Specimen Type: EDTA Plasma; Platelet Poor EDTA Plasma recommended; contact PBI for collection instructions
Biological or Clinical Significance:

Matrix MetalloProteinases (MMPs) are zinc-dependent endopeptidases that catalyze degradation of extracellular matrix proteins, thereby controlling such processes as development, tissue remodeling, wound healing...
https://pacbio.com/biomarker/assay-detail/172

TNFa (Tissue Necrosis Factor alpha)

Analyte: Tumor Necrosis Factor - α
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Tumor necrosis factor α (TNF-α), also known as cachectin, and tumor necrosis factor β (TNF-β) also known as lymphotoxin, are two closely related proteins (about 34% amino acid residue homology) that bind...
https://pacbio.com/biomarker/assay-detail/68

VCAM-1 (Vascular Adhesion Molecule-1) - Chemiluminescence

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance:

VCAM-1 ( Vascular Cell Adhension Protein 1), also known as CD106, binds to leukocyte integrins VLA-4 and Integrin alpha 4 beta 7. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell...
https://pacbio.com/biomarker/assay-detail/410

VCAM-1 (Vascular Adhesion Molecule-1)

Analyte: Vascular Adhesion Molecule-1
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Human Vascular Cell Adhesion Molecule-1 (VCAM-1) is a 100-110 kDa1 715 amino acid type I transmembrane glycoprotein typically characterized by the presence of seven C2-type immunoglobulin (Ig) domains. ...
https://pacbio.com/biomarker/assay-detail/167

VEGF-A (Vasclular Endothelial Growth Factor-A)

Analyte: Vasclular Endothelial Growth Factor-A
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor A is a protein that in humans is encoded by the VEGF-A gene. It is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-A...
https://pacbio.com/biomarker/assay-detail/381

VEGF-C (Vasclular Endothelial Growth Factor-C)

Analyte: Vasclular Endothelial Growth Factor-C
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor C is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-C is expressed in various tissues, but is not produced in peripheral...
https://pacbio.com/biomarker/assay-detail/384

VEGF-D (Vasclular Endothelial Growth Factor-D)

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor D is a protein that in humans is encoded by the FIGF gene. It belongs to the PDGF/VEGF growth factor family and highly expressed in lung, heart, small intestine and fetal lung,...
https://pacbio.com/biomarker/assay-detail/388

VEGF-R1 (Vasclular Endothelial Growth Factor-R1)

Analyte: Vasclular Endothelial Growth Factor-C
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor receptor 3 is a protein that in humans is encoded by the FLT4 gene. It belongs to the class III subfamily of receptor tyrosine kinases (RTKs). This receptor contains seven immunoglobulin-like...
https://pacbio.com/biomarker/assay-detail/385

VEGF-R2 (Vasclular Endothelial Growth Factor-R2)

Analyte: Vasclular Endothelial Growth Factor-R2
Specimen Type: Serum
Biological or Clinical Significance:

VEGF-R2 ( Vascular Endothelial Growth Factor Receptor 2) belongs to the class III subfamily of receptor tyrosine kinases (RTKs). PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF...
https://pacbio.com/biomarker/assay-detail/387

VEGF-R3 (Vasclular Endothelial Growth Factor-R3)

Analyte: Vasclular Endothelial Growth Factor-R3
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor receptor 3 is a protein that in humans is encoded by the FLT4 gene. It belongs to the class III subfamily of receptor tyrosine kinases (RTKs). This receptor contains seven immunoglobulin-like...
https://pacbio.com/biomarker/assay-detail/391

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