Biomarker Menu

Biomarker Category: Cardiovascular

ADMA (Asymmetric Dimethylarginine)

Analyte: Asymmetric Dimethyl Arginine
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. It is formed during proteolysis of methylated proteins and removed by renal excretion or metabolic degradation by the enzyme dimethylarginine...
https://pacbio.com/biomarker/assay-detail/80

CXCL-12 SDF-1 (Stromal Cell Derived Factor-1)

Analyte: Stromal Cell Derived Factor-1
Specimen Type: PlatletPoor EDTA Plasma
Biological or Clinical Significance:

SDF-1 alpha or stromal derived factor 1 alpha (also known as  CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines...
https://pacbio.com/biomarker/assay-detail/339

Galectin-3

Analyte: Galectin-3
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Galectin-3 is a structurally unique member of a family of beta-galactosidase-binding lectins.  Expression of galectin-3 has been associated with the epithelium and inflammatory cells including macrophages,...
https://pacbio.com/biomarker/assay-detail/315

gp130 (Gycoprotein 130)

Analyte: Gycoprotein 130
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

Interleukin 6 (IL-6) is a multifunctional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis.  IL-6 exerts its activity through binding to a high...
https://pacbio.com/biomarker/assay-detail/164

HMGB1 (High Motility Group Box 1 Protein)

Analyte: High Mobility Group Box 1
Specimen Type: Serum
Biological or Clinical Significance:

HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone nuclear protein group.  HMGB1 is a transcriptional regulator and is normally present...
https://pacbio.com/biomarker/assay-detail/313

hs-CRP (Highly-Sensitive C-Reactive Protein)

Analyte: C-Reactive Protein
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

C-reactive protein is the classic acute phase protein in inflammatory reactions. It is synthesized by the liver and consists of five identical polypeptide chains forming a five-membered ring of molar mass 120,000...
https://pacbio.com/biomarker/assay-detail/39

IL-1b / Il-ra ratio

Analyte: IL-1b / Il-ra ratio
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/400

IL-1Ra (Interleukin 1 Receptor Antagonist)

Analyte: Interleukin-1 soluble receptor antagonist
Specimen Type: Serum
Biological or Clinical Significance:

Interleukin-1 receptor antagonist (IL-1ra; also known as IL-1F3) is a 22 – 25 kDa member of the IL-1 family of cytokines.  IL-1ra is a pure cytokine receptor antagonist that has no signal transduction-initiating...
https://pacbio.com/biomarker/assay-detail/284

IL-1ß (Interleukin-1ß)

Analyte: Interleukin-1β
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Interleukin 1 (IL-1) includes two distinct proteins, IL-1α and IL-1β, that play central roles in acute and chronic inflammation, both locally and systemically. Human IL-1β is synthesized as a procytokine (269...
https://pacbio.com/biomarker/assay-detail/125

IL-2 Ra (Interleukin 2 Soluble Receptor alpha)

Analyte: sIL-2Rα
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

The biological activities of IL-2 are mediated by its binding to a multi-molecular cellular receptor complex. The receptor consists of three glycoprotein chains, an alpha chain (IL-2 Rα), a beta chain (IL-2...
https://pacbio.com/biomarker/assay-detail/66

IL-6 (Interleukin-6)

Analyte: Interleukin - 6
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Interleukin 6 (IL-6) is a multifunctional cytokine that has a major role in initiation and promulgation of the inflammatory and immune responses.

The biological activities of IL-6 are initiated by...
https://pacbio.com/biomarker/assay-detail/42

MCP-1 (Monocyte Chemotactic Protein-1) - chemi

Analyte: Monocyte Chemotactic Protein-1
Specimen Type: Serum
Biological or Clinical Significance:

Monocyte Chemotactic Protein-1 (MCP-1), also known as CCL2, MCAF and TDCF, is encoded by the human JE gene. It belongs to the CC chemokine family. The MCP proteins chemoattract and activate monocytes, activated...
https://pacbio.com/biomarker/assay-detail/407

MCP-1 (Monocyte Chemotactic Protein-1) -ELISA

Analyte: Monocyte Chemotactic Protein-1
Specimen Type: Serum, EDTA plasma
Biological or Clinical Significance:

Monocyte chemotactic protein 1 (MCP-1/CCL2), also known as monocyte chemotactic and activating factor (MCAF), is a member of the CC subgroup of the chemokine superfamily.  MCP-1 has the ability to act as...
https://pacbio.com/biomarker/assay-detail/139

NT-ProBNP (N-Terminal Pro B-Type Natriuretic Peptide)*

Analyte: N-terminal ProB-type Natriuretic Peptide
Specimen Type: Serum, Heparin Plasma, EDTA Plasma
Biological or Clinical Significance:

The clinical utility of CNH assays for B-type natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) has been confirmed for screening of heart disease, stratification of patients...
https://pacbio.com/biomarker/assay-detail/156

Pro-BNP (N-terminal pro-B Type Natriuretic Peptide)

Analyte: N-terminal Pro B-type Natriuretic Peptide
Specimen Type: Serum, plasma (heparin, EDTA)
Biological or Clinical Significance:

The clinical utility of CNH assays for B-type natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) has been confirmed for screening of heart disease, stratification of patients...
https://pacbio.com/biomarker/assay-detail/287

SDF-1 (Stromal Cell Derived Factor-1) (CXCL-12)

Analyte: Stromal Cell Derived Factor-1
Specimen Type: Platelet Poor EDTA Plasma; please contact PBI for collection information
Biological or Clinical Significance:

SDF-1 alpha or stromal derived factor 1 alpha (also known as  CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines...
https://pacbio.com/biomarker/assay-detail/335

Troponin I

Analyte: Troponin I
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/429

Troponin T

Analyte: Troponin T
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/176

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