Biomarker Menu

Biomarker Category: Endocrine Function

ACTH (Adrenalcorticotrophic Hormone)

Analyte: Adrenal Corticotrophic Hormone
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Determination of Adrenocorticotropic hormone (ACTH) is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal...
https://pacbio.com/biomarker/assay-detail/201

Aldosterone

Analyte: Aldosterone
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Aldosterone (11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al), produced in the adrenal cortex, is the most potent mineralocorticoid in humans. As with other steroid hormones, aldosterone is synthesized from cholesterol...
https://pacbio.com/biomarker/assay-detail/342

Cortisol

Analyte: Cortisol
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Cortisol (hydrocortisone) is the most prominent glucocorticosteroid, and is essential for the maintenance of several body functions.  Like other glucocorticosteroids, cortisol is synthesized from the common...
https://pacbio.com/biomarker/assay-detail/92

DHEA-S (Dehydroepiandrosterone Sulfate)

Analyte: Dehydroepiandrosterone Sulfate
Specimen Type: Serum
Biological or Clinical Significance:

Measurement of dehydroepiandrosterone sulfate (DHEA-SO4), an adrenal steroid, is used in investigations of abnormal hair growth (hirsutism) and balding (alopecia) in women. It is also employed in the assessment...
https://pacbio.com/biomarker/assay-detail/97

EPO (Erythropoietin)

Analyte: Erythropoietin
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Erythropoietin (Epo) is a glycoprotein hormone consisting of 165 amino acids with four complex carbohydrate chains attached to the peptide at four linkage sites. It has a molecular weight of 36 kilodaltons, 40%...
https://pacbio.com/biomarker/assay-detail/406

Estradiol

Analyte: Estradiol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Estradiol (estradiol-17β, E2) is a steroidal estrogen with a molecular mass of 272.3 daltons which circulates predominantly protein-bound.

Estrogenic hormones are secreted at varying rates during the...
https://pacbio.com/biomarker/assay-detail/104

FSH (Follicle Stimulating Hormone)

Analyte: Follicle Stimulating Hormone
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/109

HGH (Human Growth Hormone)

Analyte: Human Growth Hormone
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

GH testing is not recommended for general screening. It is primarily ordered on those with symptoms of growth hormone abnormalities, as a follow-up to other abnormal hormone test results, or to help evaluate...
https://pacbio.com/biomarker/assay-detail/118

IGF-1 (Insulin-Like Growth Factor-1)

Analyte: Insulin-like Growth Factor-1
Specimen Type: Serum, Heparin Plasma
Biological or Clinical Significance:

Insulin-like growth factor I is a single polypeptide chain with three intramolecule disulfide bonds. It consists of 70 amino acid residues with a molecular mass of 7,649 daltons. It is structurally homologous...
https://pacbio.com/biomarker/assay-detail/122

IGFBP-3 (Insulin-Like Growth Factor Binding Protein-3)

Analyte: Insulin-like Growth Factor Binding Protein-3
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Insulin-like growth factors (IGF-1, IGF-II) are a family of peptides involved in the regulation of cell growth, the actions of which are mediated by binding to the insulin-like growth factor binding proteins....
https://pacbio.com/biomarker/assay-detail/123

Intact PTH (2nd Generation Intact Parathyroid Hormone)

Analyte: Parathyroid Hormone, Intact
Specimen Type: Serum,Inquire for additional option(s)
Biological or Clinical Significance:

Parathyroid hormone (parathyrin, PTH), a single-chain polypeptide containing 84 amino acids, is synthesized and secreted by the parathyroid glands. PTH undergoes proteolysis in the liver but also in the kidneys...
https://pacbio.com/biomarker/assay-detail/44

LH (Luteinizing Hormone)

Analyte: Luteinizing Hormone
Specimen Type: Serum
Biological or Clinical Significance:

Luteinizing hormone (lutropin, LH), a glycoprotein of 28,000 daltons, is secreted by the b-cells of the anterior pituitary under the control of the hypothalamic gonadotropin releasing hormone (GnRH). LH consists...
https://pacbio.com/biomarker/assay-detail/133

Progesterone

Analyte: Progesterone
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/157

Prolactin

Analyte: Prolactin
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Prolactin is secreted by the anterior pituitary gland and controlled by the hypothalamus. It is structurally related to growth hormone (GH), but has few, if any, of the physiological effects of GH. The major...
https://pacbio.com/biomarker/assay-detail/210

SHBG (Sex Hormone-Binding Globulin)

Analyte: Sex Hormone Binding Globulin
Specimen Type: Serum
Biological or Clinical Significance:

Sex hormone-binding globulin (SHBG) is the blood transport protein for testosterone and estradiol. It is a large glycoprotein with a molecular weight of about 95 kD.

Testosterone circulates...
https://pacbio.com/biomarker/assay-detail/165

T3 (Triiodothyronine)

Analyte: Triiodothyronine
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/168

T4 (Thyroxine)

Analyte: Thyroxine
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/169

Testosterone, Total

Analyte: Testosterone, Total
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

The androgen testosterone (17β-hydroxyadrostenone) has a molecular weight of 288 daltons. In men, testosterone is synthesized almost exclusively by the leydig cells of the testes. The secretion of testosterone...
https://pacbio.com/biomarker/assay-detail/170

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance:

Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to...
https://pacbio.com/biomarker/assay-detail/408

TGF ß-1 (Transforming Growth Factor ß-1) - ELISA

Analyte: Transforming Growth Factor ß-1
Specimen Type: Platlet Poor EDTA Plasma; Please contact PBI for collection instructions
Biological or Clinical Significance:

Transforming growth factor (TGF), a ‘factor’ that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter...
https://pacbio.com/biomarker/assay-detail/171

TGF ß-1 (Transforming Growth Factor ß-1), Urine

Analyte: Transforming Growth Factor ß-1
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/431

TSH - Thyroid-stimulating hormone

Analyte: TSH
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Thyroid-stimulating hormone (TSH, thyrotropin) is a glycoprotein with a molecular weight of approx. 30,000 daltons and consisting of two subunits non-covalently bound. The beta-subunit carries the TSH-specific...
https://pacbio.com/biomarker/assay-detail/177

Whole PTH (3rd Generation Whole Parathyroid Hormone)

Analyte: Parathyroid Hormone, Whole
Specimen Type: EDTA Plasma; Contact PBI for additional options
Biological or Clinical Significance:

Parathyroid hormone (parathyrin, PTH), a single-chain polypeptide containing 84 amino acids, is synthesized and secreted by the parathyroid glands. PTH undergoes proteolysis in the liver but also in the kidneys...
https://pacbio.com/biomarker/assay-detail/70

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