Biomarker Menu

Biomarker Category: Bone Formation

BAP (Bone Alkaline Phosphatase)

Analyte: Bone Alkaline Phosphatase
Specimen Type: Serum
Biological or Clinical Significance:

Bone is constantly undergoing a metabolic process called remodeling. This includes a degradation process, bone resorption, mediated by the action of osteoclasts and a building process, bone formation, mediated...
https://pacbio.com/biomarker/assay-detail/13

Calcium

Analyte: Calcium
Specimen Type: Serum, Heparin Plasma
Biological or Clinical Significance:

Calcium is the major material used in mineralization of bones. The calcium content of an adult is somewhat over 1 kg (25000 mmol), i.e. about 2% of the body weight. Of this, 99% is present as calcium hydroxyapatite...
https://pacbio.com/biomarker/assay-detail/15

Calcium, Urine

Analyte: Calcium
Specimen Type: Urine (24h w preservative) * Please contact PBI for collection instructions.
Biological or Clinical Significance:

The calcium content of an adult is somewhat over 1 kg (25,000 mmol), i.e. about 2% of the body weight. Of this, 99% is present as calcium hydroxyapatite in bones and less than 1% is present in the extraosseous...
https://pacbio.com/biomarker/assay-detail/424

CICP (PICP) (C-Propeptide of Type I Procollagen)

Analyte: C-Propeptide of Type I Procollagen
Specimen Type: Serum
Biological or Clinical Significance:

Type 1 Collagen is a primary organic constituent of bone. The release of these peptides into the circulation as the result of the cleavage of type I collagen (CICP) provides a stoichiometric representation of...
https://pacbio.com/biomarker/assay-detail/93

Intact PTH (2nd Generation Intact Parathyroid Hormone)

Analyte: Parathyroid Hormone, Intact
Specimen Type: Serum,Inquire for additional option(s)
Biological or Clinical Significance:

Parathyroid hormone (parathyrin, PTH), a single-chain polypeptide containing 84 amino acids, is synthesized and secreted by the parathyroid glands. PTH undergoes proteolysis in the liver but also in the kidneys...
https://pacbio.com/biomarker/assay-detail/44

OC (Osteocalcin) - ECL

Analyte: Osteocalcin
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Osteocalcin, a 49 amino acid peptide is the major noncollagen protein of bone. It contains three gamma-carboxyglutamic acid (GLA) residues at positions 17, 21 and 24 and is, therefore, also known as bone gla-protein...
https://pacbio.com/biomarker/assay-detail/411

OC (Osteocalcin) - ELISA

Analyte: Osteocalcin
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Osteocalcin, or bone Gla protein (BGP), is the major non-collagenous protein of bone matrix. It has a molecular weight of approximately 5800 Dalton and consists of 49 amino acids, including three residues of...
https://pacbio.com/biomarker/assay-detail/52

OPG (Osteoprotegerin)

Analyte: Osteoprotegerin
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues; it has a molecular weight of 60...
https://pacbio.com/biomarker/assay-detail/150

OPN (Osteopontin), Plasma

Analyte: Osteopontin
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein.  Its putative functions include roles in bone metabolism, immune regulation, wound healing,...
https://pacbio.com/biomarker/assay-detail/299

OPN (Osteopontin), Urine

Analyte: Osteopontin
Specimen Type: Urine
Biological or Clinical Significance:

Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein.  Its putative functions include roles in bone metabolism, immune regulation, wound healing,...
https://pacbio.com/biomarker/assay-detail/303

PINP (N-Terminal Propeptide of Type I Collagen) - ECL

Analyte: Aminoterminal Propeptide of Type I Collagen
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix. During bone formation collagen type I is synthesized from pro-collagen type I, which is...
https://pacbio.com/biomarker/assay-detail/56

PINP (N-Terminal Propeptide of Type I Collagen) - RIA

Analyte: Aminoterminal Propeptide of Type I Collagen
Specimen Type: Serum
Biological or Clinical Significance:

Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix.  During bone formation, collagen type I is synthesized from pro-collagen type I,...
https://pacbio.com/biomarker/assay-detail/318

Vitamin D, 1,25-(OH)2 (1.25 dihydroxy Vitamin D)

Analyte: Vitamin D, 1,25 - Dihydroxy
Specimen Type: Serum, Inquire for additional options(s)
Biological or Clinical Significance:

Vitamin D, also known as caliciferal; is a group of fat-soluble secosteroids, the two major physiologically revlevant forms of which are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D...
https://pacbio.com/biomarker/assay-detail/182

Vitamin D, 25 - OH (25-hydroxy vitamin D2+D3)

Analyte: Vitamin D, 25-hydroxy
Specimen Type: Serum Inquire for additional option(s)
Biological or Clinical Significance:

Vitamin D, also known as caliciferal; is a group of fat-soluble secosteroids, the two major physiologically revlevant forms of which are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D...
https://pacbio.com/biomarker/assay-detail/183

Vitamin K

Analyte: Vitamin K
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/184

Whole PTH (3rd Generation Whole Parathyroid Hormone)

Analyte: Parathyroid Hormone, Whole
Specimen Type: EDTA Plasma; Contact PBI for additional options
Biological or Clinical Significance:

Parathyroid hormone (parathyrin, PTH), a single-chain polypeptide containing 84 amino acids, is synthesized and secreted by the parathyroid glands. PTH undergoes proteolysis in the liver but also in the kidneys...
https://pacbio.com/biomarker/assay-detail/70

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