Biomarker Menu

Biomarker Category: Lipoprotein Components

Apolipoprotein A-I

Analyte: Apolipoprotein AI
Specimen Type: Serum (preferred), EDTA Plasma
Biological or Clinical Significance:

Apolipoproteins are components of plasma lipoproteins. They play a role in the structure, function, and metabolism of lipoproteins.

Apo A-I, the predominant protein, constitutes approximately 60% of...
https://pacbio.com/biomarker/assay-detail/6

Apolipoprotein A-I, Urine

Analyte: Apolipoprotein AI
Specimen Type: Urine
Biological or Clinical Significance:

Human Apolipoprotein A-I (apo A-I) comprises about 70% of the high-density lipoproteins (HDL) protein mass, while apo A-II makes up another 15 – 20%.  Apo A-I, a 243-amino acid molecule that contains a...
https://pacbio.com/biomarker/assay-detail/357

Apolipoprotein A-II

Analyte: Apolipoprotein A-II
Specimen Type: Serum, Inquire for addtional option(s)
Biological or Clinical Significance:

Apolipoproteins are the protein components of lipoproteins in plasma and determine the structure, function, and metabolism of lipoproteins. Apolipoprotein A-I and A-II constitute about 90% of the total HDL protein....
https://pacbio.com/biomarker/assay-detail/78

Apolipoprotein B

Analyte: Apolipoprotein B
Specimen Type: Serum preferred, EDTA Plasma
Biological or Clinical Significance:

The enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Human plasma LDL consists of approximately 21% protein by weight, of which approximately 90% is apolipoprotein B100....
https://pacbio.com/biomarker/assay-detail/9

Apolipoprotein B-100

Analyte: Apolipoprotein B-100
Specimen Type: Serum preferred
Biological or Clinical Significance:

Human plasma low density lipoproteins (LDL) consist of approximately 21% protein by weight, of which approximately 90% is apolipoprotein B. Numerous studies have indicated that measurements of Apo B are useful...
https://pacbio.com/biomarker/assay-detail/7

Apolipoprotein B-48

Analyte: Apolipoprotein B-48
Specimen Type: Serum,EDTA Plasma
Biological or Clinical Significance:

Apolipoprotein B48 (ApoB48) is the primary protein component of the chylomicrons (CM). The lipid and other components of the particle are organized about a single ApoB48 molecule. ApoB48 is specifically distributed...
https://pacbio.com/biomarker/assay-detail/8

Apolipoprotein C-II

Analyte: Apolipoprotein C-II
Specimen Type: Serum and EDTA plasma
Biological or Clinical Significance:

Apolipoproteins are components of lipoproteins in plasma and are important in determining the structure, function and metabolism of lipoproteins. Apolipoprotein C-II is contained in very low density lipoproteins...
https://pacbio.com/biomarker/assay-detail/10

Apolipoprotein C-III

Analyte: Apolipoprotein C-III
Specimen Type: Serum,EDTA Plasma
Biological or Clinical Significance:

Apolipoprotein-lipid complexes are referred to as lipoproteins.  The apolipoproteins are plasma protein components that complex with cholesterol, cholesterol esters, glycerides (triglycerides, etc.) and...
https://pacbio.com/biomarker/assay-detail/11

Apolipoprotein E

Analyte: Apolipoprotein E
Specimen Type: Serum,EDTA Plasma
Biological or Clinical Significance:

Apolipoprotein E is a 299 amino acid, arginine – rich glycoprotein. The major source of synthesis and secretion is liver parenchymal cells, which secrete Apo E in association with VLDL particles. Apo E is also...
https://pacbio.com/biomarker/assay-detail/12

Apolipoprotein J (Clusterin), Urine

Analyte: Clusterin
Specimen Type: Urine
Biological or Clinical Significance:

Clusterin (also know as apolipoprotein J, sulfated glycoprotein 2 (SGP-2), TRPM-2, and SP-40) is a secreted multifunctional protein that was named for its ability to induce cellular clustering.  It binds...
https://pacbio.com/biomarker/assay-detail/196

Chylomicron Component Apolipoprotein B

Analyte: Chylomicron Component Apolipoprotein B
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Chylomicrons are particles that have a density less than 0.94 mg/mL. They are large triglyceride-rich lipoproteins that arise from the small intestine, where they are synthesized in enterocytes from apolipoproteins...
https://pacbio.com/biomarker/assay-detail/331

Chylomicron Component Cholesterol

Analyte: Chylomicron Component Cholesterol
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Chylomicrons are particles that have a density less than 0.94 mg/mL. They are large triglyceride-rich lipoproteins that arise from the small intestine, where they are synthesized in enterocytes from apolipoproteins...
https://pacbio.com/biomarker/assay-detail/18

Chylomicron Component Triglyceride

Analyte: Chylomicron Component Triglyceride
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

The determination of Apolipoprotein A-I and B can help to assess the degree of atherosclerotic risk. Even in borderline cases, which are not usually detected during routine determination of cholesterol, triglycerides,...
https://pacbio.com/biomarker/assay-detail/330

HDL Preβ-1 (HDL Prebeta 1)

Analyte: Pre ß1 High-Density Lipoprotein
Specimen Type: EDTA plasma with stabilizer recommended; please contact PBI for collection information
Biological or Clinical Significance:

Pre β1-HDL is a discoid-shaped HDL particle of approximately 67 kDa that migrates with pre-β electrophoretic mobility on agarose gels. It contains apolipoprotein A-I (Apo AI), phospholipids and unesterified...
https://pacbio.com/biomarker/assay-detail/366

HDL- C Direct (Homogeneous)

Analyte: HDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

HDL cholesterol (HDL-C) is a powerful inverse predictor of risk of coronary heart disease (CHD). Guidelines published by the American Heart Association (AHA) and the National Cholesterol Education Program (NCEP),...
https://pacbio.com/biomarker/assay-detail/99

HDL-Apolipoproteins A-I

Analyte: HDL Apolipoproteins AI
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Apolipoproteins are components of plasma lipoproteins. They play a role in the structure, function, and metabolism of lipoproteins.

Apo A-I, the predominant protein, constitutes approximately...
https://pacbio.com/biomarker/assay-detail/327

HDL-Apolipoproteins A-II

Analyte: HDL Apolipoproteins AII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Apolipoproteins are the protein components of lipoproteins in plasma and determine the structure, function, and metabolism of lipoproteins. Apolipoprotein A-I and A-II constitute about 90% of the total HDL protein....
https://pacbio.com/biomarker/assay-detail/372

HDL-Apolipoproteins C-II

Analyte: HDL Apolipoproteins CII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Apolipoproteins are components of lipoproteins in plasma and are important in determining the structure, function and metabolism of lipoproteins. Apolipoprotein C-II is contained in very low density lipoproteins...
https://pacbio.com/biomarker/assay-detail/373

HDL-Apolipoproteins C-III

Analyte: HDL Apolipoproteins CIII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Apolipoprotein-lipid complexes are referred to as lipoproteins.  The apolipoproteins are plasma protein components that complex with cholesterol, cholesterol esters, glycerides (triglycerides, etc.) and...
https://pacbio.com/biomarker/assay-detail/374

HDL-Apolipoproteins E

Analyte: HDL Apolipoproteins E
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Apolipoprotein E is a 299 amino acid, arginine – rich glycoprotein. The major source of synthesis and secretion is liver parenchymal cells, which secrete Apo E in association with VLDL particles. Apo E is also...
https://pacbio.com/biomarker/assay-detail/375

HDL-C Polyethylene Glycol

Analyte: HDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

HDL cholesterol (HDL-C) is a powerful inverse predictor of risk of coronary heart disease (CHD). Guidelines published by the American Heart Association (AHA) and the National Cholesterol Education Program (NCEP),...
https://pacbio.com/biomarker/assay-detail/85

HDL-C Precipitation Dextran Sulfate

Analyte: HDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

HDL cholesterol (HDL-C) is a powerful inverse predictor of risk of coronary heart disease (CHD). Guidelines published by the American Heart Association (AHA) and the National Cholesterol Education Program (NCEP),...
https://pacbio.com/biomarker/assay-detail/36

HDL-C Precipitation Heparin/Manganese

Analyte: HDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

HDL cholesterol (HDL-C) is a powerful inverse predictor of risk of coronary heart disease (CHD). Guidelines published by the American Heart Association (AHA) and the National Cholesterol Education Program (NCEP),...
https://pacbio.com/biomarker/assay-detail/84

HDL-C Subclasses by Precipitation (HDL2/HDL3)

Analyte: HDL subfractions HDL2/HDL3
Specimen Type: Serum
Biological or Clinical Significance:

HDL subclasses are separated by selective precipitation using dextran sulfate (50 kDa) and Mg2+ followed by quantitation of cholesterol in the total-HDL and HDL-3 fractions; the HDL-2 cholesterol content is obtained...
https://pacbio.com/biomarker/assay-detail/115

HDL-C Ultracentrifugation

Analyte: HDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

HDL cholesterol (HDL-C) is a powerful inverse predictor of risk of coronary heart disease (CHD). Guidelines published by the American Heart Association (AHA) and the National Cholesterol Education Program (NCEP),...
https://pacbio.com/biomarker/assay-detail/37

HDL-Triglyceride

Analyte: HDL Triglyceride
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Glycerol concentrations in fresh, fasting serum are usually in the 1 mg/dL range (levels may go up in samples that are not promptly processed and analyzed, or if refrigerated for extended periods).  Determination...
https://pacbio.com/biomarker/assay-detail/326

LDL-Apolipoprotein B

Analyte: LDL Apolipoprotein B
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

The enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Human plasma LDL consists of approximately 21% protein by weight, of which approximately 90% is apolipoprotein B100....
https://pacbio.com/biomarker/assay-detail/325

LDL-C Direct (Homogeneous)

Analyte: LDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Plasma lipoproteins are spherical particles that contain varying amounts of cholesterol, triglycerides, phospholipids and proteins. The phospholipid, free cholesterol and protein constitute the outer surface...
https://pacbio.com/biomarker/assay-detail/98

LDL-C Ultracentrifugation (β-Quantification)

Analyte: LDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Plasma lipoproteins are spherical particles that contain varying amounts of cholesterol, triglycerides, phospholipids and proteins. The phospholipid, free cholesterol and protein constitute the outer surface...
https://pacbio.com/biomarker/assay-detail/72

LDL-C, Friedewald (calculated)

Analyte: LDL Cholesterol
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Plasma lipoproteins are spherical particles that contain varying amounts of cholesterol, triglycerides, phospholipids and proteins. The phospholipid, free cholesterol and protein constitute the outer surface...
https://pacbio.com/biomarker/assay-detail/108

LDL-Triglyceride

Analyte: LDL-Triglyceride
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Glycerol concentrations in fresh, fasting serum are usually in the 1 mg/dL range (levels may go up in samples that are not promptly processed and analyzed, or if refrigerated for extended periods).  Determination...
https://pacbio.com/biomarker/assay-detail/324

Lp (a) [Lipoprotein (a)]

Analyte: Lipoprotein (a)
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Lipoprotein (a) [Lp(a)] was discovered as a genetic variant in low density lipoproteins (LDL) in 1963 by Berg (see reference 1). Lp(a) is a lipoprotein whose protein moiety is comprised of two major apolipoproteins,...
https://pacbio.com/biomarker/assay-detail/47

NMR (Nuclear Magnetic Resonance)

Analyte: Lipoprotein Fractionation
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/377

RLP-Apo B (Remnant Lipoprotein Apolipoprotein B)

Analyte: Remnant Lipoprotein- Apolipoprotein B
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/332

RLP-B48 (Remnant Lipoprotein Apolipoprotein B-48)

Analyte: Remnant Lipoprotein- Apolipoprotein B-48
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/162

RLP-C (Remnant Lipoprotein Cholesterol)

Analyte: Remnant Lipoprotein-Cholesterol
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Plasma triglycerides (TG), which reflect the sum of all the TG in plasma lipoproteins, are considered a weak risk-factor for the development of atherosclerosis.  Recent research has shown that certain fractions...
https://pacbio.com/biomarker/assay-detail/61

RLP-TG (Remnant Lipoprotein Triglyceride)

Analyte: Remnant Lipoprotein - Triglyceride
Specimen Type: Serum, EDTA Plasma,Inquire for additional option(s)
Biological or Clinical Significance:

Plasma triglycerides (TG), which reflect the sum of all the TG in plasma lipoproteins, are considered a weak risk-factor for the development of atherosclerosis.  Recent research has shown that certain fractions...
https://pacbio.com/biomarker/assay-detail/62

sdLDL (Small Dense LDL) (Direct)

Analyte: Small Dense LDL Cholesterol
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

The sdLDL-C “Seiken” is a simple method for the quantitative determination of small, dense low density lipoprotein (LDL) cholesterol for research use only. LDL-cholesterol is a critical risk factor for developing...
https://pacbio.com/biomarker/assay-detail/64

VLDL-Apolipoproteins B

Analyte: VLDL Apolipoproteins B
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

The enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Human plasma LDL consists of approximately 21% protein by weight, of which approximately 90% is apolipoprotein B100....
https://pacbio.com/biomarker/assay-detail/329

VLDL-Apolipoproteins C-II

Analyte: VLDL Apolipoproteins CII
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Apolipoproteins are components of lipoproteins in plasma and are important in determining the structure, function and metabolism of lipoproteins. Apolipoprotein C-II is contained in very low density lipoproteins...
https://pacbio.com/biomarker/assay-detail/369

VLDL-Apolipoproteins C-III

Analyte: VLDL Apolipoproteins CIII
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Apolipoprotein-lipid complexes are referred to as lipoproteins.  The apolipoproteins are plasma protein components that complex with cholesterol, cholesterol esters, glycerides (triglycerides, etc.) and...
https://pacbio.com/biomarker/assay-detail/370

VLDL-Apolipoproteins E

Analyte: VLDL Apolipoproteins E
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Apolipoprotein E is a 299 amino acid, arginine – rich glycoprotein. The major source of synthesis and secretion is liver parenchymal cells, which secrete Apo E in association with VLDL particles. Apo E is also...
https://pacbio.com/biomarker/assay-detail/371

VLDL-C (Cholesterol) by ultracentrifugation

Analyte: VLDL Cholesterol
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Plasma lipoproteins are spherical particles that contain varying amounts of cholesterol, triglycerides, phospholipids and proteins. The phospholipid, free cholesterol and protein constitute the outer surface...
https://pacbio.com/biomarker/assay-detail/185

VLDL-C, Friedwald (calculated)

Analyte: VLDL Cholesterol
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Plasma lipoproteins are spherical particles that contain varying amounts of cholesterol, triglycerides, phospholipids and proteins. The phospholipid, free cholesterol and protein constitute the outer surface...
https://pacbio.com/biomarker/assay-detail/328

VLDL-Triglyceride

Analyte: VLDL Triglyceride
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Glycerol concentrations in fresh, fasting serum are usually in the 1 mg/dL range (levels may go up in samples that are not promptly processed and analyzed, or if refrigerated for extended periods).  Determination...
https://pacbio.com/biomarker/assay-detail/186

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