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Biomarker Category: Bone Resorption

CTX (C-Terminal Telopeptides of Type I Collagen), Urine

Analyte: C-terminal telopeptides of type I collagen
Specimen Type: Urine
Biological or Clinical Significance:

Type I collagen CTX accounts for more than 90% of the organic matrix of bone and is synthesized primarily in bone. During renewal of the skeleton, type I collagen is degraded, and small peptide fragments are...
https://pacbio.com/biomarker/assay-detail/21

CTX (C-Terminal Telopeptides Type I Collagen), Serum/Plasma ECL

Analyte: C-terminal telopeptides of type I collagen
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Beta C-terminal telopeptide (β-CTX) is a specific resorption marker for degradation of bone type I collagen by osteoclasts. More than 90% of organic bone matrix consists of type I collagen, which is primarily...
https://pacbio.com/biomarker/assay-detail/20

DKK-1 (Dickkopf-Related Protein-1)

Analyte: DKK-1
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Dickkopf related protein 1 (Dkk-1) was the first identified member of the Dickkopf family of secreted proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy.  Dickkopf (meaning “stubborn”...
https://pacbio.com/biomarker/assay-detail/297

DPD Free (Deoxypyridinoline), Urine

Analyte: Deoxypyridinoline, free
Specimen Type: Urine (unpreserved 1st or 2nd void)
Biological or Clinical Significance:

Approximately 90% of the organic matrix of bone is type I collagen, a triple helical protein.  Type I collagen of bone is crosslinked by specific molecules which provide rigidity and strength.  Crosslinks...
https://pacbio.com/biomarker/assay-detail/353

DPD Total (Deoxypyridinoline), Serum

Analyte: Deoxypyridinoline, Total
Specimen Type: Serum
Biological or Clinical Significance:

Bone is constantly undergoing a metabolic process called remodeling. This includes a degradation process, bone resorption, mediated by the action of osteoclasts, and a building process, bone formation, mediated...
https://pacbio.com/biomarker/assay-detail/100

DPD Total (Deoxypyridinoline), Urine

Analyte: Deoxypyridinoline, Total
Specimen Type: Urine (unpreserved 1st or 2nd morning void)
Biological or Clinical Significance:

Bone is constantly undergoing a metabolic process called remodeling. This includes a degradation process, bone resorption, mediated by the action of osteoclasts, and a building process, bone formation, mediated...
https://pacbio.com/biomarker/assay-detail/101

ICTP (CTX-MMP)

Analyte: C-Terminal Telopeptide Type I Collagen, CTX-MMP
Specimen Type: Serum
Biological or Clinical Significance:

Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen, ICTP, is the carboxyterminal telopeptide of type I collagen, joined through trivalent crosslinks and released during the degradation...
https://pacbio.com/biomarker/assay-detail/40

NTx (N-Telopeptides of Type I Collagen), Serum

Analyte: N-Telopeptide Type I Collagen
Specimen Type: Serum
Biological or Clinical Significance:

Bone resorption is a function of osteoclasts. These cells remove the mineral from bone and break down the organic matrix, which is primarily comprised of type I collagen. Collagen is a cross-linked fibrous protein...
https://pacbio.com/biomarker/assay-detail/149

NTx (N-Telopeptides of Type I Collagen), Urine

Analyte: N-Telopeptide Type I Collagen
Specimen Type: Urine (2nd morning void preferred; do not add preservative)
Biological or Clinical Significance:

Bone resorption is a function of osteoclasts.  These cells remove the mineral from bone and break down the organic matrix that is primarily comprised of type I collagen.  Collagen is a cross-linked...
https://pacbio.com/biomarker/assay-detail/148

Phosphorus, Inorganic

Analyte: Phosphorus, Inorganic
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

88% of the phosphorous contained in the body is localized in bone in the form of calcium phosphate as the apatite Ca2+ [Ca3 (PO4 ) 2 ] 2-3. The remainder is involved in intermediary carbohydrate metabolism and...
https://pacbio.com/biomarker/assay-detail/154

PYD Free (Pyridinoline)

Analyte: Pyridinoline
Specimen Type: Serum
Biological or Clinical Significance:

Structural collagens such as types I and II that are present in bone and cartilage, respectively, are crosslinked both within their α-chains and between adjacent molecules to provide rigidity and strength to...
https://pacbio.com/biomarker/assay-detail/160

PYD, Total (Pyridinoline)

Analyte: Pyridinoline
Specimen Type: Serum
Biological or Clinical Significance:

The Serum PYD assay provides a quantitative measure of the excretion of pyridinoline crosslinks in serum. Structural collagens such as types I and II that are present in bone and cartilage, respectively, are...
https://pacbio.com/biomarker/assay-detail/267

RANK-L (Receptor Activitor for Nuclear Factor B Ligand)

Analyte: RANK-L
Specimen Type: Serum
Biological or Clinical Significance:

sRANKL, receptor activator of nuclear factor (NF)-κB ligand (also: osteoprotegerin ligand, OPGL), is a part of the TNF superfamily with high similarity to other members of that protein species. RANKL, RANK,...
https://pacbio.com/biomarker/assay-detail/161

SOST (Sclerostin)

Analyte: Sclerostin
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/415

TRACP-5b (Tartrate-Resistant Acid Phosphatase-5b)

Analyte: Tartrate-resistant acid phosphatase-5b
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Tartrate-resistant acid phosphatase (TRACP) is expressed in bone-resorbing osteoclasts and secreted into the circulation. Thus, serum TRACP has been considered as a potentially useful marker of bone resorption...
https://pacbio.com/biomarker/assay-detail/69

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