Biomarker Menu

Biomarker Category: Cartilage Diseases and Arthritis

Anti-CCP (Anti-Cyclic Citrullinated Peptide)

Analyte: Anti-Cyclic Citrullinated Peptide
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by the inflammation of the membrane lining joints. The most frequent serological test in the diagnosis of RA is the measurement of rheumatoid...
https://pacbio.com/biomarker/assay-detail/5

C1C2 (C1C2 Neopitope)

Analyte: C1C2 Neopitope
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/354

C2C (Collagen Type II Cleavage), Urine

Analyte: Collagen Type II Cleavage
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/355

C2C (Collagend Type II Cleavage), Serum

Analyte: Collagen Type II Cleavage
Specimen Type: Serum
Biological or Clinical Significance:

Joint cartilage is composed of a type II collagen-based fibrillar network complexed to proteoglycans. Type II collagen consists of three identical α chains arranged in a triple helix that form fibrils. Small-diameter...
https://pacbio.com/biomarker/assay-detail/89

COMP (Cartilage Oligomeric Matrix Protein)

Analyte: Cartilage Oligomeric Matrix Protein
Specimen Type: Serum,EDTA Plasma
Biological or Clinical Significance:

Cartilage Oligomeric Matrix Protein (COMP) is a non-collagen protein in the matrix of articular cartilage (1). COMP has a molecular mass of 434 kDa consisting of five identical disulfide linked subunits. It is...
https://pacbio.com/biomarker/assay-detail/414

CS-846 (Aggrecan)

Analyte: Aggrecan
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/3

CTX-II (Carboxy-Terminal Telepeptides of Type II Collagen), Urine

Analyte: C-Telopeptide Type II Collagen, CartiLaps
Specimen Type: Urine
Biological or Clinical Significance:

Bone is constantly undergoing a metabolic process called remodeling. This includes a degradation process, bone resorption, and a building process, bone formation. Crosslinked telopeptides collagens are the products...
https://pacbio.com/biomarker/assay-detail/95

HA (Hyaluronic Acid)

Analyte: Hyaluronic acid
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Hyaluronic Acid (HA), also known as hyaluronate or hyaluronan, is a glycosaminoglycan – a high molecular weight polysaccharide with an unbranched backbone composed of alternating sequences of β-(1-3)-N-acetylglucosamine...
https://pacbio.com/biomarker/assay-detail/119

HMGB1 (High Motility Group Box 1 Protein)

Analyte: High Mobility Group Box 1
Specimen Type: Serum
Biological or Clinical Significance:

HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone nuclear protein group.  HMGB1 is a transcriptional regulator and is normally present...
https://pacbio.com/biomarker/assay-detail/313

ICTP (CTX-MMP)

Analyte: C-Terminal Telopeptide Type I Collagen, CTX-MMP
Specimen Type: Serum
Biological or Clinical Significance:

Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen, ICTP, is the carboxyterminal telopeptide of type I collagen, joined through trivalent crosslinks and released during the degradation...
https://pacbio.com/biomarker/assay-detail/40

PIIINP (N-Terminal Propeptide of Type III Collagen)

Analyte: Procollagen Type III N-Propeptide
Specimen Type: Serum, Heparin Plasma, Inquire for additional options(s)
Biological or Clinical Significance:

Type III (PIIINP) collagen is derived from a larger protein, type III procollagen. Increased concentrations of PIIINP are found in a number of conditions where accumulation and/or degradation of connective tissue...
https://pacbio.com/biomarker/assay-detail/55

Rheumatoid Factor Isotypes (IgA, IgG & IgM)

Analyte: Rheumatoid Factor Isotypes (IgA, IgG & IgM)
Specimen Type: Serum
Biological or Clinical Significance:

RF describes an antibody (IgM, IgG and IgA) that is directed toward antigenic determinants present on human and animal IgG. RF-IgM activity is detected by latex agglutination, nephelometry, radioimmunoassay (RIA)...
https://pacbio.com/biomarker/assay-detail/60

YKL-40

Analyte: YKL-40
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

YKL-40, also known as human cartilage glycoprotein 39 (HC gp-39), is a 40 kilodalton glycoprotein first described in whey secretions of nonlactating cows. Subsequently, its production by chondrocytes,...
https://pacbio.com/biomarker/assay-detail/187

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