Biomarker Menu

Biomarker Category: Oncology

Ang-2 (Angiopoietin-2)

Analyte: Angiopoietin-2
Specimen Type: Serum
Biological or Clinical Significance:

 Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.  It belongs to the angiopoietin protein family (angiopoietin-1, -2, -3, and -4) which plays an important role in the development...
https://pacbio.com/biomarker/assay-detail/382

April (A Proliferation-inducing Ligand)

Analyte: A Proliferation-Inducing Ligand
Specimen Type: Serum
Biological or Clinical Significance:

APRIL (A PRoliferation-Inducing Ligand) is a member of the tumor necrosis factor family. APRIL shows high levels of expression in tumors of different origin and low level of expression in normal cells. APRIL...
https://pacbio.com/biomarker/assay-detail/418

BCMA (B-cell Maturation Antigen)

Analyte: B-cell Maturation Antigen
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

BCMA, B cell maturation antigen, is a member of the TNF receptor superfamily.  It has been designated TNFRSF17.  BCMA is a type III membrane protein containing one extracellular cysteine rich domain....
https://pacbio.com/biomarker/assay-detail/419

BMP-9 (Bone Morphogenic Protein-9)

Analyte: Bone Morphogenic Protein-9
Specimen Type: Serum
Biological or Clinical Significance:

Bone Morphogenetic Protein 9 (BMP-9), also known as growth differentiation factor 2 (GDF2), is encoded by the human CDF2  gene.  It belongs to the TGF-β cytokine family whose members play an important...
https://pacbio.com/biomarker/assay-detail/390

C-MET

Analyte: C-MET
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

Recent observations have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis, which is an independent prognostic indicator of recurrence...
https://pacbio.com/biomarker/assay-detail/383

CA 9 (Carbonic Anhydrase IX)

Analyte: Carbonic Anhydrase IX
Specimen Type: Serum
Biological or Clinical Significance:

Carbonic anhydrase IX (CA9, also known as membrane antigen MN) is a member of the carbonic anhydrase protein family.  It is a transmembrane protein that consists of an N-terminal signal peptide, an extracellular...
https://pacbio.com/biomarker/assay-detail/403

CA-125 (Cancer Antigen 125)

Analyte: Cancer Antigen 125
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

CA 125 belongs to the family of hybridoma-defined tumor markers. The antigenic determinant CA 125 has a protein structure with associated carbohydrate side-chains.

CA 125 is found in a high percentage...
https://pacbio.com/biomarker/assay-detail/365

CA19-9 (Carbohydrate Antigen 19-9)

Analyte: Carbohydrate Antigen 19-9
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

The CA 19-9 (carbohydrate antigen 19-9) values measured are defined by the use of the monoclonal antibody 1116N-NS-19-9.  The 1116-NS-19-9 reactive determinants on a glycolipid having a molecular weight...
https://pacbio.com/biomarker/assay-detail/404

CTX (C-Terminal Telopeptides of Type I Collagen), Urine

Analyte: C-terminal telopeptides of type I collagen
Specimen Type: Urine
Biological or Clinical Significance:

Type I collagen CTX accounts for more than 90% of the organic matrix of bone and is synthesized primarily in bone. During renewal of the skeleton, type I collagen is degraded, and small peptide fragments are...
https://pacbio.com/biomarker/assay-detail/21

CTX (C-Terminal Telopeptides Type I Collagen), Serum/Plasma ECL

Analyte: C-terminal telopeptides of type I collagen
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Beta C-terminal telopeptide (β-CTX) is a specific resorption marker for degradation of bone type I collagen by osteoclasts. More than 90% of organic bone matrix consists of type I collagen, which is primarily...
https://pacbio.com/biomarker/assay-detail/20

Endoglin

Analyte: Endoglin
Specimen Type: Serum
Biological or Clinical Significance:

Endoglin, also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for transforming growth factor beta (TGF-β) superfamily ligands. It is highly expressed on vascular...
https://pacbio.com/biomarker/assay-detail/389

HE-4 (Human Epididymis Protein 4)

Analyte: Human Epididymis Protein 4
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:

The human epididymal protein 4 (HE4) belongs to the family of whey acidic four-disulfide core proteins with suspected trypsin inhibitor properties.  The corresponding gene codes for a 13 kDa protein. ...
https://pacbio.com/biomarker/assay-detail/417

HGF (Human Growth Factor)

Analyte: Human Growth Hormone
Specimen Type: Serum
Biological or Clinical Significance:

Hepatocyte growth factor (HGF), also known as Hepatopoietin A, is mitogenic for a variety of cell types, including endothelial and epithelial cells, melanocytes, and keratinocytes. HGF signals through a transmembrane...
https://pacbio.com/biomarker/assay-detail/392

HMGB1 (High Motility Group Box 1 Protein)

Analyte: High Mobility Group Box 1
Specimen Type: Serum
Biological or Clinical Significance:

HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone nuclear protein group.  HMGB1 is a transcriptional regulator and is normally present...
https://pacbio.com/biomarker/assay-detail/313

IL-8 (Interleukin-8)

Analyte: Interleukin-8
Specimen Type: Serum
Biological or Clinical Significance:

Interleukin 8 (IL-8) or CXCL8 is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells. It induces chemotaxis in target cells, primarily neutrophils but...
https://pacbio.com/biomarker/assay-detail/393

PINP (N-Terminal Propeptide of Type I Collagen) - ECL

Analyte: Aminoterminal Propeptide of Type I Collagen
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix. During bone formation collagen type I is synthesized from pro-collagen type I, which is...
https://pacbio.com/biomarker/assay-detail/56

PINP (N-Terminal Propeptide of Type I Collagen) - RIA

Analyte: Aminoterminal Propeptide of Type I Collagen
Specimen Type: Serum
Biological or Clinical Significance:

Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix.  During bone formation, collagen type I is synthesized from pro-collagen type I,...
https://pacbio.com/biomarker/assay-detail/318

PlGF (Placental Growth Factor)

Analyte: Placental Growth Factor
Specimen Type: Serum
Biological or Clinical Significance:

PlGF (Placental Growth Factor) is a member of the VEGF family of growth factor that share a conserved pattern of eight cysteines.PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF...
https://pacbio.com/biomarker/assay-detail/386

VEGF-A (Vasclular Endothelial Growth Factor-A)

Analyte: Vasclular Endothelial Growth Factor-A
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor A is a protein that in humans is encoded by the VEGF-A gene. It is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-A...
https://pacbio.com/biomarker/assay-detail/381

VEGF-C (Vasclular Endothelial Growth Factor-C)

Analyte: Vasclular Endothelial Growth Factor-C
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor C is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-C is expressed in various tissues, but is not produced in peripheral...
https://pacbio.com/biomarker/assay-detail/384

VEGF-D (Vasclular Endothelial Growth Factor-D)

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor D is a protein that in humans is encoded by the FIGF gene. It belongs to the PDGF/VEGF growth factor family and highly expressed in lung, heart, small intestine and fetal lung,...
https://pacbio.com/biomarker/assay-detail/388

VEGF-R1 (Vasclular Endothelial Growth Factor-R1)

Analyte: Vasclular Endothelial Growth Factor-C
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor receptor 3 is a protein that in humans is encoded by the FLT4 gene. It belongs to the class III subfamily of receptor tyrosine kinases (RTKs). This receptor contains seven immunoglobulin-like...
https://pacbio.com/biomarker/assay-detail/385

VEGF-R2 (Vasclular Endothelial Growth Factor-R2)

Analyte: Vasclular Endothelial Growth Factor-R2
Specimen Type: Serum
Biological or Clinical Significance:

VEGF-R2 ( Vascular Endothelial Growth Factor Receptor 2) belongs to the class III subfamily of receptor tyrosine kinases (RTKs). PlGF binds and signals through VEGF R1/Flt-1 but not VEGF R2/Flk-1/KDR, while VEGF...
https://pacbio.com/biomarker/assay-detail/387

VEGF-R3 (Vasclular Endothelial Growth Factor-R3)

Analyte: Vasclular Endothelial Growth Factor-R3
Specimen Type: Serum
Biological or Clinical Significance:

Vascular endothelial growth factor receptor 3 is a protein that in humans is encoded by the FLT4 gene. It belongs to the class III subfamily of receptor tyrosine kinases (RTKs). This receptor contains seven immunoglobulin-like...
https://pacbio.com/biomarker/assay-detail/391

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