Biomarker Menu

Biomarker Category: Liver Injury

Adiponectin, Total

Analyte: Adiponectin, Total
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Adiponectin is an adipocyte-specific protein with potential roles in glucose and lipid homeostasis. It is a member of the TNF superfamily. Adiponectin is induced during adipocyte differentiation and its secretion...
https://pacbio.com/biomarker/assay-detail/2

αGST (Alpha Glutathione S-Transferase)

Analyte: Alpha-Glutathione S-Transferase
Specimen Type: Urine; first morning void preserved with stabilizing buffer
Biological or Clinical Significance:

Of significance for renal diagnostics, alpha GST is found in the proximal tubule region of the kidney, whereas the other common isoform, pi GST, is confined mainly to the distal tubules. Events that precipitate...
https://pacbio.com/biomarker/assay-detail/231

Albumin

Analyte: Albumin
Specimen Type: Serum, Inquire for addional option(s)
Biological or Clinical Significance:

Albumin is a carbohydrate-free protein, which constitutes 55–65% of total plasma protein. It maintains oncotic plasma pressure, provides transport and storage of a wide variety of ligands and is a source of...
https://pacbio.com/biomarker/assay-detail/402

Bile Acids, Total

Analyte: Total Bile Acids
Specimen Type: EDTA Plasma
Biological or Clinical Significance:

Bile acids are 24-carbon steroids formed from cholesterol in the liver.  Five major bile acid forms compose over 99% of the bile acid pool formed in body fluids. 

The liver synthesizes two primary...
https://pacbio.com/biomarker/assay-detail/343

CICP (PICP) (C-Propeptide of Type I Procollagen)

Analyte: C-Propeptide of Type I Procollagen
Specimen Type: Serum
Biological or Clinical Significance:

Type 1 Collagen is a primary organic constituent of bone. The release of these peptides into the circulation as the result of the cleavage of type I collagen (CICP) provides a stoichiometric representation of...
https://pacbio.com/biomarker/assay-detail/93

CTGF (Connective Tissue Growth Factor)

Analyte: Connective Tissue Growth Factor
Specimen Type: Serum
Biological or Clinical Significance:

CTGF, a member of the CCN protein family, is relevant in many physiological and pathological processes.  Both clinical and experimental studies have demonstrated that CTGF is overexpressed in fibrotic human...
https://pacbio.com/biomarker/assay-detail/314

FAS (APO1) (CD95)

Analyte: FAS
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance:

Fas (APO-1 or CD95) is a cell-surface receptor that transduces apoptotic signals from Fas ligand (FasL).  It is a glycoprotein with a mass estimated at 43 to 48 kDa.  Fas is a member of the Tumor Necrosis...
https://pacbio.com/biomarker/assay-detail/225

HA (Hyaluronic Acid)

Analyte: Hyaluronic acid
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

Hyaluronic Acid (HA), also known as hyaluronate or hyaluronan, is a glycosaminoglycan – a high molecular weight polysaccharide with an unbranched backbone composed of alternating sequences of β-(1-3)-N-acetylglucosamine...
https://pacbio.com/biomarker/assay-detail/119

HMGB1 (High Motility Group Box 1 Protein)

Analyte: High Mobility Group Box 1
Specimen Type: Serum
Biological or Clinical Significance:

HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone nuclear protein group.  HMGB1 is a transcriptional regulator and is normally present...
https://pacbio.com/biomarker/assay-detail/313

hs-CRP (Highly-Sensitive C-Reactive Protein)

Analyte: C-Reactive Protein
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:

C-reactive protein is the classic acute phase protein in inflammatory reactions. It is synthesized by the liver and consists of five identical polypeptide chains forming a five-membered ring of molar mass 120,000...
https://pacbio.com/biomarker/assay-detail/39

Paraoxonase-1 Activity (PON-1)

Analyte: Paraoxonase-1 Activity
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Paraoxonase is a single glycoprotein that is able to hydrolyze aromatic carboxylic acid esters as well as organophosphate compounds. It is closely associated with HDL particles and has a molecular mass of 43...
https://pacbio.com/biomarker/assay-detail/53

Paraoxonase-1 Mass (PON-1)

Analyte: Paraoxonase-1 Mass
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/338

PIIINP (N-Terminal Propeptide of Type III Collagen)

Analyte: Procollagen Type III N-Propeptide
Specimen Type: Serum, Heparin Plasma, Inquire for additional options(s)
Biological or Clinical Significance:

Type III (PIIINP) collagen is derived from a larger protein, type III procollagen. Increased concentrations of PIIINP are found in a number of conditions where accumulation and/or degradation of connective tissue...
https://pacbio.com/biomarker/assay-detail/55

PON-1 Activity (Paraoxonase-1)

Analyte: Paraoxonase-1 Activity
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Paraoxonase is a single glycoprotein that is able to hydrolyze aromatic carboxylic acid esters as well as organophosphate compounds. Because of these alternative substrates, this enzyme has been called arylester...
https://pacbio.com/biomarker/assay-detail/246

PON-1 Mass (Paraoxonase-1)

Analyte: Paraoxonase-1 Mass
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/360

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance:

Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to...
https://pacbio.com/biomarker/assay-detail/408

TGF ß-1 (Transforming Growth Factor ß-1) - ELISA

Analyte: Transforming Growth Factor ß-1
Specimen Type: Platlet Poor EDTA Plasma; Please contact PBI for collection instructions
Biological or Clinical Significance:

Transforming growth factor (TGF), a ‘factor’ that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter...
https://pacbio.com/biomarker/assay-detail/171

TGF ß-1 (Transforming Growth Factor ß-1), Urine

Analyte: Transforming Growth Factor ß-1
Specimen Type: For information on this assay, please contact PBI.
Biological or Clinical Significance:
https://pacbio.com/biomarker/assay-detail/431

TIMP-1 (Tissue Inhibitor of Metalloproteinase-1)

Analyte: Tissue Inhibitor of Metalloproteinases-1
Specimen Type: EDTA Plasma; Platelet Poor EDTA Plasma recommended; contact PBI for collection instructions
Biological or Clinical Significance:

Matrix MetalloProteinases (MMPs) are zinc-dependent endopeptidases that catalyze degradation of extracellular matrix proteins, thereby controlling such processes as development, tissue remodeling, wound healing...
https://pacbio.com/biomarker/assay-detail/172

TNFa (Tissue Necrosis Factor alpha)

Analyte: Tumor Necrosis Factor - α
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance:

Tumor necrosis factor α (TNF-α), also known as cachectin, and tumor necrosis factor β (TNF-β) also known as lymphotoxin, are two closely related proteins (about 34% amino acid residue homology) that bind...
https://pacbio.com/biomarker/assay-detail/68

Type IV Collagen

Analyte: Type IV Collagen
Specimen Type: Serum
Biological or Clinical Significance:

Chronic liver disease comprises a number of progressive disorders which culminate in liver cirrhosis and which are characterized by excessive deposition of collagen. Although various types of collagen (type I,...
https://pacbio.com/biomarker/assay-detail/230

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